With a new and rapidly moving subject, it is always a question at what point one is justified in summarizing current knowledge in book form. Dr. Herrell's monograph will always be a landmark in the history of antibiotics, if for no other reason than for the excellent chapters dealing with the discovery and development of these substances, the analysis of the literature and the classification of priorities. The general physician will perhaps be most interested in the discussions of technic of preparation and administration of penicillin and of the results of treatment in various conditions. The material is extensive and well presented, although much will have to be revised in the light of future (and indeed current) work, especially the matter of time-dose relation. The reviewer feels that the continuous intravenous method of administration will, except in rare instances, be replaced by intermittent intramuscular injections or by some other more
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