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EFFECT OF INTRAVENOUSLY ADMINISTERED SOLUTION OF ACACIA ON ANIMALS

RAYMOND E. SMALLEY, M.D.; MELVIN W. BINGER, M.D.; JESSE L. BOLLMAN, M.D.; MARSCHELLE H. POWER, Ph.D.
Arch Intern Med (Chic). 1945;76(1):39-46. doi:10.1001/archinte.1945.00210310047006.
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Considerable attention has been focused on intravenous administration of solution of acacia, the probable physiologic and physical action of acacia so administered and its fate in the organism. The study herein reported was a long term investigation of dogs which had received intravenously large doses of a solution of acacia similar to that used in treatment of patients who display the resistant edema that may accompany glomerulonephritis and the nephrotic syndrome. The purpose was to note the general effect on the animals as well as the specific effect on the liver.

MATERIAL AND METHODS  Three normal adult dogs, which were receiving a diet of ground raw meat, cracker meal and milk in daily amounts calculated to maintain their body weight, were used in this study. Beginning on Jan. 7, 1942, each dog received intravenous injections of 6 per cent acacia in 0.06 per cent isotonic solution of sodium chloride, as

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