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REVERSAL OF LINGUAL ATROPHIC CHANGES WITH NICOTINAMIDE THERAPY

ELMER L. SEVRINGHAUS, M.D.; EMMA D. KYHOS, M.D.
Arch Intern Med (Chic). 1945;76(1):31-33. doi:10.1001/archinte.1945.00210310039004.
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Description by Kruse1 (1942) of the changes in the tongues of a group of adults which were reversed toward normal by the daily administration of 200 mg. of nicotinamide led us to make an attempt to establish the validity of these conclusions in the prison population which we have been studying. The description of the diet used by these men has been given by Kyhos and associates2 (1944), and it suggested that extreme deficiencies of nicotinic acid were not to be expected. The amounts of meat served and eaten were variable but never large. The bread used was baked in the prison and, so far as we can learn, was not made from enriched flour. The diet was not too different from what is used by a large part of the population engaged in industry, or in agriculture, and therefore the observations may well be applicable to the

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