It has become widely recognized that the kidney may be damaged in the course of therapy with sulfonamide compounds. Such renal complications may be classified roughly as follows: 1. Mechanical complications produced by masses of crystals of the sulfonamide compounds in the kidneys, pelves and ureters. These lead to obstructive lesions. This group may be further subdivided into (a) the extranephric, in which the concretions causing obstruction are within the pelves of the kidney or in the ureters, and (b) the intranephric, in which the concretions are in the kidney substance itself. 2. Toxic intrarenal lesions without mechanical obstruction. These lesions occur within the kidney and are not associated with mechanical obstruction but may be attributed to the toxic effect of the sulfonamide compound on the parenchymal tissue. This class may be divided into three groups, which represent different phases of the same reaction and are not distinct divisions: (a)
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