Arch Intern Med (Chic). 1944;73(2):123-130. doi:10.1001/archinte.1944.00210140013002.
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As a result of the experiments of Goldblatt1 by which he demonstrates that hypertension can be produced in experimental animals by the application of a silver clamp to one or both renal arteries and of the publication of papers by Longcope2 and Weiss and Parker3 indicating the role of pyelonephritis in the pathogenesis of hypertension, a new approach to the treatment of hypertension in selected cases was gained, which at that time gave promise of considerable success. Physicians began to search especially for unilateral renal lesions in patients with elevated blood pressure in the hope of relieving the hypertension by removal of the affected kidney. Butler,4 in 1937, was apparently the first to report a cure of hypertension by removal of a single pyelonephritic kidney. Since that time many reports have appeared in the literature concerning the treatment of hypertension by unilateral nephrectomy, and many more


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