The anemia produced by accelerated disintegration of red blood cells leading to jaundice, increased excretion of urobilinogen and moderate splenomegaly often is accompanied by morphologic alterations of the red cells and usually is classified as hemolytic anemia. In a few instances the process may be truly hemolytic in the strict meaning of the word. However, in a majority neither the mechanism of the destruction of the red cell nor the fate of its stroma is known. I shall therefore employ the word "hemolysis" in its loose, hematologic rather than in its narrower, immunologic meaning throughout this discussion unless a clear distinction is specified.
I have observed a number of patients presenting hemolytic icterus of unknown cause with an acute or a subacute course similar to those whose cases were reported earlier by Widal and by Chauffard and their associates. In addition I have records of a number of patients with