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July 1943, Vol 72, No. 1 >
ARTICLE | July 1943

IN SITU EFFECTS OF ANTACIDS IN DUODENAL ULCER

J. EDWARD BERK; MARTIN E. REHFUSS, M.D.; J. EARL THOMAS, M.D.
Arch Intern Med (Chic). 1943;72(1):46-57. doi:10.1001/archinte.1943.00210070054005.
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An attempt at neutralization of the acid gastric juice is one of the basic purposes common to most of the conventional methods of treatment of peptic ulcer. In order to secure more effective neutralization it has become rather universal practice to employ any of several antacid medications, all of which have been extolled for their peculiar virtues and each of which has its own group of proponents. Alkaline substances continue to succeed one another in favor, largely as their several advocates are able to demonstrate a greater degree of reduction or a more prolonged reduction of acidity in the stomach.

The concerted efforts directed toward modification of gastric acidity are natural outgrowths of the emphasis which has been laid on the acid factor in ulcer. It is surprising, however, that so much attention has been given to gastric acidity when the vast majority of the ulcers encountered clinically are situated

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