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MORPHOLOGY OF ERYTHROCYTES IN ERYTHROBLASTOSIS FOETALIS

EDWARD H. REISNER Jr.
Arch Intern Med (Chic). 1943;71(2):230-255. doi:10.1001/archinte.1943.00210020096007.
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Acute hemolytic anemias due to autoantibody reactions have been observed in human beings1 and induced experimentally in animals.2 Hematologic examination of the experimental animals has revealed a fairly consistent pattern of morphologic change. During the initial phase of hemolysis, the mean cell diameter decreases and the mean cell volume increases, the cells assuming a spheroid shape. After several days the mean diameter rises above normal with the simultaneous appearance of macrocytes, nucleated red cells and increased numbers of reticulocytes. At this time the Price-Jones curve is frequently bimodal, and Dameshek has stressed this point as being of diagnostic import in such anemias. The recent work of Levine and his associates3 has shown that about 90 per cent of infants with erythroblastosis foetalis have an antigen, designated as Rh, in their blood cells which is inherited from the father, probably as a mendelian dominant character, and which the

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