0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

INTERMEDIATE ACTION OF MIXTURES OF SOLUBLE INSULIN AND PROTAMINE ZINC INSULIN

ARTHUR R. COLWELL, M.D.; JOSEPH LEWIS IZZO, M.D.; WALTER A. STRYKER, Ph.D., M.D.
Arch Intern Med (Chic). 1942;69(6):931-951. doi:10.1001/archinte.1942.00200180002001.
Text Size: A A A
Published online

From the standpoint of clinical usefulness in cases of severe diabetes neither of the two standard insulins, soluble insulin and protamine zinc insulin, is ideal for routine day by day use. Because it is in solution, ordinary insulin is absorbed rapidly and within a short time exerts a strong effect which fades quickly. Hence it must be given frequently, and in excess it tends to cause violent hypoglycemic symptoms. With soluble insulin alone it is impossible to control severe diabetes in many cases unless multiple daily injections are given, including one during the normal sleeping hours. The same is true of solution of zinc insulin crystals, or crystalline insulin, the action of which is practically identical with that of ordinary insulin.1 Protamine zinc insulin eliminates some of these disadvantages because it releases insulin slowly. Its effects are slow in onset, weak until reenforced by repeated overlapping doses but slow

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();