Last year one of us (K. B.)1 reported his experience with alpha lobeline hydrochloride as an agent for measuring the velocity of blood flow, a method originally proposed by Teplov and Sor.2 Its advantages and disadvantages were commented on, and the conclusion was reached that it was a practical method for testing "circulation time." We then planned to employ the test in evaluating the progress of patients who were under treatment for heart failure. The day to day variations observed in the same patient were considerable, and it occurred to us that factors other than changes in the degree of heart failure might be operative. To investigate this problem, a series of duplicate measurements was performed, the results of which are presented here.
DESCRIPTION OF TEST
The technic of the test has been previously outlined in detail1; a brief description will suffice here. Three to 5 mg. of