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THERAPEUTIC AND PROPHYLACTIC DETOXICATION OF SULFANILAMIDE, SULFAPYRIDINE AND SULFATHIAZOLE

GUSTAV J. MARTIN, Sc.D.; C. VIRGINIA FISHER, Ph.D.; MARVIN R. THOMPSON, Ph.D.
Arch Intern Med (Chic). 1942;69(4):662-669. doi:10.1001/archinte.1942.00200160113009.
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The process of aiding the body with sulfanilamide compounds in its fight against a specific bacterial invasion presents simultaneously to the body toxic chemicals which it must detoxify. The processes used by the body in detoxication are oxidation, reduction and conjugation. Frequently, oxidation and reduction precede conjugation. The compounds involved in conjugative detoxication are well known; no attempt will be made to review the extensive material as various excellent reviews on the subject are available.1 There is a certain specificity exhibited in the processes of detoxication. The compounds involved are aminoacetic acid, choline, cystine, glucuronic acid, glutamine, sulfates, acetates and ornithine.

The chemotherapeutic efficacy of the sulfanilamide compounds-sulfanilamide, sulfapyridine (2- [paraaminobenzenesulfonamido]-pyridine), sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole, etc.— against infections caused by such organisms as streptococci, pneumococci and staphylococci is well established. These compounds are toxic per se, manifesting in human beings a variety of symptoms.2

A consideration of the literature on

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