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INTRAVENOUS USE OF SODIUM SULFADIAZINE IN THE TREATMENT OF PNEUMOCOCCIC PNEUMONIA

ALBERT H. DOMM, M.D.; HARRISON F. FLIPPIN, M.D.; JOHN G. REINHOLD, Ph.D.; LEON SCHWARTZ, M.D.
Arch Intern Med (Chic). 1942;69(1):51-57. doi:10.1001/archinte.1942.00200130061005.
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In previous papers we have reported on the behavior of sulfadiazine (2-[paraaminobenzenesulfonamido]-pyridine) in normal subjects,1 and its use in the treatment of pneumococcic pneumonia.2 Oral therapy with sulfadiazine2 was supplemented with intravenous administration of the sodium salt of sulfadiazine in certain instances when rapid elevation of the level of the drug in the blood was desired. The behavior of the drug when given by vein suggested that administration of the entire dose of sulfadiazine by the intravenous route might be advantageous. Observations on the intravenous use of sodium sulfadiazine3 without oral therapy in the treatment of pneumococcic pneumonia are described in the present paper.

MATERIAL AND METHOD 

Intravenous Administration of Sodium Sulfadiazine to Normal Subjects.  —As a guide to the therapeutic use of sodium sulfadiazine the fate of this compound administered by vein was first investigated in normal subjects (table 1). Five adult males with normal

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