Clinical Diabetes Mellitus and Hyperinsulinism.

Here is the long-awaited presentation in monograph form of Dr. Wilder's past experiences and present day views in the field of diseases of carbohydrate metabolism. Although he limits his thesis to a consideration of procedures useful in the diagnosis and treatment of diabetes mellitus and hyperinsulinism, he keeps his subject matter alive and stimulating by the use of argumentative footnotes. The material is well organized and written in a plain, readable style.

The initial chapter, on the normal homeostasis of the blood sugar and the various regulatory mechanisms involved in normal carbohydrate metabolism, serves admirably to introduce Dr. Wilder's definition and diagnostic standards of diabetes mellitus in its varied clinical forms. He adheres strictly to the unitarian concept of diabetes mellitus as a disease characterized by a persistently abnormal metabolism due to a real or relative insufficiency of the insulinogenic ability of the pancreas. In the discussion on the varied