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Vitamin D: Chemistry, Physiology, Pharmacology, Pathology, Experimental and Clinical Investigations.

Arch Intern Med (Chic). 1941;67(2):471-472. doi:10.1001/archinte.1941.00200020233019.
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This monograph is an excellent review and evaluation of the recent literature on vitamin D and includes, in addition, the results of numerous investigations by the authors. The chemistry and various forms of the vitamin and the methods of chemical and biologic assay are first discussed. Subsequent chapters deal with the physiology of vitamin D and its relation to rickets and to the parathyroid glands. The influence of vitamin D on energy metabolism, mineral metabolism, resistance to infection and blood constituents is considered in detail. Two chapters are devoted to the toxic effects of large doses of various forms of this vitamin. Good results are reported from the use of vitamin D in the treatment of arthritis, and other possible therapeutic applications are indicated. Throughout the book emphasis is placed on problems which need further investigation. When controversial subjects are discussed, tentative interpretations are offered but no final conclusions are


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