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February 1941, Vol 67, No. 2 >
ARTICLE | February 1941

DISEASES OF NUTRITION:  REVIEW OF CERTAIN RECENT CONTRIBUTIONS

HUGH R. BUTT, M.D.; WILLIAM V. LEARY, M.D.
Arch Intern Med (Chic). 1941;67(2):411-465. doi:10.1001/archinte.1941.00200020173011.
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Within the past year vitamins again have been the main attraction in the study of nutrition. More and more evidence has accumulated to indicate that vitamins form an integral part of the enzyme system of the body and that clinical deficiencies of vitamins are usually multiple rather than singular. In addition, the broad aspect of national defense has again brought forward many timely discussions of national standards of nutrition and the controversial issue of fortification of foods. These general advances have been supplemented by numerous experimental and chemical contributions to knowledge of each separate vitamin, but space allows detailed discussion only of those of the greatest clinical significance.

VITAMIN A 

Chemical and Physiologic Properties.  —It appears from recent reports that the chemical structure of vitamin (A1) is closely related to that of vitamin A2. Most observations are in accord with the view that vitamin A2 contains the

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