This is a comprehensive study of the nature of the hypertension that occurs in dogs after the suitable application of Goldblatt clamps to the renal arteries. In the first chapter technics for the measurement of the blood pressure of a dog are discussed and the author's preference for the method of Loman and Dameshek is defended. Chapter 2 reviews briefly experimental methods for producing hypertension in dogs. The distinctive features of the type of hypertension provoked by renal ischemia, as described by other workers, are noted, and Fasciolo presents his own experiments to confirm them. These features may be briefly noted:
Unilateral partial occlusion of a renal artery causes (usually) a temporary hypertension.
Partial occlusion of both renal arteries causes a persistent and more severe hypertension, which may not be accompanied, at least early, by the retention of nitrogenous material in the blood.
The hypertension resulting from unilateral clamping is: