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Arch Intern Med (Chic). 1940;66(5):1079-1086. doi:10.1001/archinte.1940.00190170070004.
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In the past few years there has been considerable interest in the relationship between carbohydrate metabolism and vitamin B1. As Williams and Spies1 pointed out in their recent monograph: "There is convincing evidence of frequent disturbances of glycogen storage and blood sugar in B1 avitaminosis. Further indications of this are found in clinical experience. A hyperglycemia and glycosuria in depancreatized dogs which does not respond to insulin but is cured by thiamin plus riboflavin has been reported. The whole matter of vitamin B1 deficiency in relation to sugar disturbances requires further study, as the evidence of some association of the two is strong but still obscure." Monauni2 claimed that thiamine is a two-sided regulator of blood sugar, raising the level when it is subnormal and lowering it when it is elevated. Several authors3 have shown that thiamine lowers the level of blood sugar and improves the sugar tolerance curve. Unfortunately,


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