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May 1940, Vol 65, No. 5 >
ARTICLE | May 1940

USE OF ALPHA LOBELINE FOR MEASUREMENT OF VELOCITY OF BLOOD FLOW

KURT BERLINER, M.D.
Arch Intern Med (Chic). 1940;65(5):896-901. doi:10.1001/archinte.1940.00190110025003.
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Various methods for the measurement of the velocity of blood flow are now commonly employed. Most of them are subjective—they depend for their results on the cooperation of the patient; therefore, they not infrequently yield inaccurate results or fail altogether. The objective methods hitherto employed either are too complicated for ordinary clinical use or are potentially harmful to the patient. Recently the Russian authors Teplov and Sor 1 have suggested the use of alpha lobeline as an agent for the measurement of the velocity of blood flow. To my knowledge, this new, objective method for estimating "circulation time" has not yet been used in this country. I have undertaken, therefore, to investigate its merits, and I present the following preliminary report.

DESCRIPTION OF TEST  Technic.—Prior to the test the patient is kept in a reclining position for about ten minutes. No preliminary instructions are given, and any remarks which

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