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LIVER AND BILIARY TRACT A REVIEW FOR 1939

CARL H. GREENE, M.D., Ph.D.; ELLISTON FARRELL, M.D.
Arch Intern Med (Chic). 1940;65(4):847-869. doi:10.1001/archinte.1940.00190100188008.
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PHYSIOLOGY OF THE BILE ACIDS  The bile acids are formed in the liver and may be considered the specific secretion of that organ. In consequence they are recognized as the most characteristic constituent of the bile. The literature relative to the metabolism of the bile acids has been summarized in the past by Stadelmann1 and Whipple4 and most recently by Sobotka.5 The recent literature on the chemistry of the bile acids was reviewed in 1936 (Greene6). Since the last two reports there has been increasing progress in this field. These studies may be summarized under several different headings: (1) experimental and clinical studies on the effect of diet on the secretion of bile; (2) the postoperative concentration of bile salts in human bile; (3) the excretion of intravenously injected cholates; (4) experimental and clinical studies on the effect of the administration of bile salts on the composition of bile, and

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