The problem of the cytologic origin and relation of multiple myeloma has been one of the puzzles of medicine ever since Macintyre1 reported the first case nearly a hundred years ago. There are indications that the problem is approaching a solution. It is hoped that the following report of a case, particularly the correlation of its many interesting features with those reported in the literature, may contribute to a better understanding of the disease.
REPORT OF A CASE
A. W. R., a chemist aged 55, was admitted in October 1934 to the Massachusetts Memorial Hospitals, with weakness as the most prominent symptom. The historical data included fracture of the right tibia as a result of a fall in 1923, paracentesis of the left ear drum in 1928, "septic" throat in 1930 and many migrainous headaches, which had become much less severe in recent years.About six months before entering