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EXCRETION OF ASCORBIC ACID IN RELATION TO SATURATION AND UTILIZATION:  WITH SOME DIAGNOSTIC IMPLICATIONS

M. A. SPELLBERG, M.D.; ROBERT W. KEETON, M.D.
Arch Intern Med (Chic). 1939;63(6):1095-1116. doi:10.1001/archinte.1939.00180230080006.
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In the past few years numerous reports have appeared in the literature dealing with the metabolism of ascorbic acid in man. These studies made use of the Harris-Ray1 modification of the Tillman method of titrating for this substance in the urine and the Farmer-Abt2 method for its detection in blood plasma. Several general conceptions were evolved from these studies:

  1. Ascorbic acid is excreted in the urine in its reduced state in almost all persons, the exact quantity depending on the amount of intake, but the minimal normal amount is considered to be around 20 mg. per twenty-four hours.3

  2. Reduced ascorbic acid is found in the blood stream of normally nourished persons; the concentration of this is 0.7 to 0.9 mg. per hundred cubic centimeters of plasma or higher.4

  3. Ascorbic acid is stored in almost all of the tissues of the body,5 and when these body stores are filled

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