0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

DISEASES OF METABOLISM AND NUTRITION:  REVIEW OF CERTAIN RECENT CONTRIBUTIONS

RUSSELL M. WILDER, M.D., Ph.D.; DAVID I. RUTLEDGE, M.D.; DWIGHT L. WILBUR, M.D.
Arch Intern Med (Chic). 1939;63(2):356-427. doi:10.1001/archinte.1939.00180190158010.
Text Size: A A A
Published online

ENDOCRINE RELATIONS IN DIABETES MELLITUS  The primary contribution of the past year to the physiology of diabetes mellitus was the demonstration by Frank George Young,1 of University College, London, that lasting diabetes can be produced in dogs by injection of anterior pituitary extract. The preliminary report appeared in August 1937; publication of satisfactory details was made in March 1938. Hyperglycemia and glycosuria had been obtained before with similar extracts by Evans and his associates2 (1932) and by others, including Houssay and his colleagues,3 but the glycosuria in their experiments was impermanent and persisted only as long as daily injections were maintained, never much longer. Such transitory glycosuria, even with hyperglycemia, does not constitute diabetes. It can be provoked in otherwise normal men or animals by overfunction of the thyroid or adrenal glands, by irritations of the central nervous system or by drugs, particularly by anesthetics. The outstanding

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();