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Clinical and Experimental Investigations in Agranulocytosis.

Arch Intern Med (Chic). 1938;62(5):900. doi:10.1001/archinte.1938.00180160179014.
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This is an excellent piece of work, which was carried on while the author was working as a research fellow under Prof. Valdemar Bie at the Blegdam Hospital in Denmark. It represents an unusually comprehensive study of agranulocytosis based on a careful review of the literature and on 88 cases, all but 1 of the patients coming under the author's observation.

The monograph is a scholarly production. Every detail has been well worked out. The history of agranulocytosis is interestingly gathered together. The clinical description of the disease and its differential diagnosis are clear, logical and concise. The discussion of the possible etiology of the condition is especially interesting. The author argues a strong case against aminopyrine and presents striking figures to show the close parallelism in Denmark from 1926 to 1936 between the sale of aminopyrine, on the one hand, and the number of known cases of agranulocytosis, on


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