Diabetes insipidus as a clinical manifestation has long been a subject of interest and controversy. The latter has resulted in an accumulation of clinical and experimental data which has tended to clarify the concept of the mechanism of diabetes insipidus. A complete review of the literature of the subject of diabetes insipidus would literally inundate the reader with watery references. However, for want of space, reference to several notable surveys, presented from different points of view, will indicate the extent of the literature and serve as source material.
Staemmler,1 in 1932, in an extensive review of the subject up to that time, presented evidence indicating that isolated lesions involving the posterior and intermediate lobes of the pituitary body or the hypothalamus may lead to diabetes insipidus. Roussy and Mosinger2 and Leschke,3 in 1933, in separate reviews showed the evidence favoring the hypothalamic origin of diabetes insipidus. More