It has been demonstrated as a fact that digitalis decreases the cardiac output (Stewart and Cohn1 and Burwell, Neighbors and Regen2) and the cardiac size in normal human beings (Stewart and Cohn1). It was found (Stewart and Cohn1) that the cardiac output was diminished and the heart dilated in the presence of congestive heart failure and that the administration of digitalis in these instances increased the cardiac output and decreased the cardiac size. We (Stewart, Crane, Deitrick and Thompson3) have recently published data relating to patients suffering from organic heart disease, without congestive heart failure, with normal rhythm. In certain of these cases the behavior of the heart was normal; in others the behavior was like that of a failing heart. In addition, we3 have shown in these later observations that digitalis increased the work of the heart per beat. Moreover, the action of the drug was the
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