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July 1938, Vol 62, No. 1 >
ARTICLE | July 1938

INFLUENCE OF DIARRHEA ON THE VITAMIN B1 REQUIREMENT

MARGARET DANN, M.D., Ph.D.; GEORGE R. COWGILL, Ph.D.
Arch Intern Med (Chic). 1938;62(1):137-150. doi:10.1001/archinte.1938.00180120145004.
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Chronic diarrhea occurs as a symptom in a great variety of diseases (table 1). In the management of the majority of these conditions, one of the problems of prime importance is the assurance of an adequate supply of dietary essentials. Without intending to minimize the importance of mineral constituents or of the other substances known to be necessary in the diet, we present this study concerned with one particular aspect of the problem, namely, the amount of vitamin B1 which may be required by patients suffering from diarrhea. The literature contains abundant clinical evidence that disorders due to dietary deficiencies, usually multiple but particularly of the vitamins of the B complex, occur as complications of chronic diseases of the alimentary tract. Signs and symptoms of pellagra and beriberi have been observed in carcinoma of the gastrointestinal tract (Rolph,1 1916; Eusterman and O'Leary,2 1931), in ulcerative colitis (Barnes,

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