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SEVERE ANEMIA OF APLASTIC TYPE ASSOCIATED WITH SCLEROSIS OF THYROID GLAND

R. H. JAFFÉ, M.D.
Arch Intern Med (Chic). 1938;61(1):19-25. doi:10.1001/archinte.1938.00180070024002.
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In a previous publication I1 described a sclerosing disease of the thyroid gland which affects elderly women and is associated with marked hypochromic or hyperchromic anemia. Since the patients do not show signs of myxedema, the grave disturbance of the thyroid gland is likely to be overlooked unless a basal metabolism test is made. The lack of response to liver or iron medication then leads to the conclusion that one is dealing with an obscure primary anemia which cannot be classified. Study of the structure of the blood cells and of the hemoglobin metabolism does not help much in gaining any definite information as to the nature of the anemia, and in the terminal stage a blood picture may develop which is suggestive of aplastic anemia. The recent observation of an additional case that falls into this group induces me again to emphasize the importance of endocrine disturbances, particularly

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