Obstructive jaundice produces anatomic changes in the kidneys consisting chiefly of degeneration of the tubular epithelium, long familiar to pathologists under the name cholemic nephrosis. The resulting disturbances in renal function, although recognized by clinicians, have received relatively little recent study. In the present report are given the observations made on a group of patients with obstructive jaundice on whom tests of renal function were employed in an effort to delineate more carefully the clinical features of the renal lesion and to determine the severity and the course. The results indicate that clinically detectable jaundice is invariably associated with the appearance of rather characteristic abnormalities of the urine and frequently with decreased renal function. The evidence of the renal lesion disappears promptly as the jaundice subsides, leaving no detectable sign of residual damage.
METHODS OF STUDY
The subjects of the investigation were sixteen patients suffering from obstructive jaundice and one
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 58
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.