The author feels that the response of fixed tissues to antigenic stimuli has not received the attention it deserves in comparison with the amount of study that has been devoted to phagocytes and circulating antibodies. He has therefore injected antigens into various tissues—most commonly the skin—of rabbits and observed the inflammatory response, the anchoring and destruction of antigen, the local necrosis and sometimes the effect on circulating antibody. Horse serum was the antigen usually employed. The immunity of tissues to bacterial or other toxins received no detailed study.
In the experimental demonstration of the importance of tissues in the response to antigens, the technologic approach is varied in many ways, and numerous features of the response are topics of discussion in the first sixteen chapters of the book. It is obviously impracticable even to list these topics here. Each chapter contains a summary and, excepting the first, a section dealing