Arch Intern Med (Chic). 1937;60(4):567-573. doi:10.1001/archinte.1937.00180040003001.
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The separation of twenty-nine new types of pneumococci from those formerly designated as group IV opened up an entirely new and promising field for investigation. It was apparent that these new types required study along the same lines that had been applied to the original three types in order to determine variations in the clinical picture, the prognosis and especially the possibility of treatment with serum. Variations in diseases due to the pneumococci of types I, II and III are well known. In the case of infection with type I pneumococci the tendency to affect young adults, the more frequent acute and typical onset, the termination by crisis and the striking response to therapy with specific serum are recognized. Infection with type II pneumococci is associated with a more protracted and more irregular course, with a high incidence of invasion of the blood stream, numerous complications, less likelihood of critical


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