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ARTICLE |

PRESENCE OF DIGITALIS IN BODY FLUIDS OF DIGITALIZED PATIENTS

MAURICE A. SCHNITKER, M.D.; SAMUEL A. LEVINE, M.D.
Arch Intern Med (Chic). 1937;60(2):240-250. doi:10.1001/archinte.1937.00180020064005.
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During the treatment of patients with congestive heart failure we have occasionally observed that from twenty-four to forty-eight hours after diuresis has been produced by the use of salyrgan or mercurin (the sodium salt of trimethylcyclopentane-dicarboxylic acid-methoxymercuryhydroxideallylamide) or with theophylline the patient has become ill, with nausea, vomiting, giddiness, headache and considerable weakness. In fact, in the past several years one of us has seen two patients, not alarmingly ill before such supplemental diuresis, come to rapid unexpected death in this sickness a day or two after salyrgan had been given. It is this occasional postdiuretic illness that initiated the present investigation.

There are several hypotheses that may be offered as an explanation of the symptoms that may follow diuresis induced with salyrgan. When given in the usual doses, of 1 or 2 cc., this drug may produce no diuresis, in which case the mercury may be retained in the

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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