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Arch Intern Med (Chic). 1936;58(6):1041-1047. doi:10.1001/archinte.1936.00170160087004.
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Determinations of the cardiac output have not often been made in cases of polycythaemia vera. Early workers, who used unreliable methods, reported no marked deviation from normal. In 1925 Liljestrand and Stenström1 found that the cardiac output was 10 per cent below normal in one case; the patient had a low basal metabolic rate (85 per cent of normal). The concentration of hemoglobin was 135 per cent, and the erythrocytes numbered 6,800,000 per cubic millimeter of blood. There was no enlargement of the spleen. The blood volume apparently was not determined. Ernst2 in 1930 reported a cardiac output 10 per cent above normal in a case in which there was a 10 to 15 per cent increase in the basal metabolic rate. A diagnosis of polycythaemia vera was not warranted in this case, as the total blood volume, instead of being increased, was low, only 70 cc. per


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