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PRESENCE IN NORMAL HUMAN URINE OF A RETICULOCYTE-STIMULATING PRINCIPLE FOR THE PIGEON

G. E. WAKERLIN, M.D.; H. D. BRUNER, M.D.
Arch Intern Med (Chic). 1936;57(5):1032-1038. doi:10.1001/archinte.1936.00170090197014.
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Recent experimental work on the etiology of pernicious anemia points to the formation in normal persons of an erythrogenic principle by the interaction of gastric juice and certain dietary constituents, subsequent absorption of the principle and storage in the liver. This process is well known to be grossly deficient in persons with pernicious anemia.1 In normal persons it appears that a sufficient concentration of this hematogenic principle is maintained in the blood stream to effect the normal maturation of the red blood cells in the bone marrow. The logic of examining urine for the presence of the hematogenic principle is therefore apparent. Moreover, renal tissue has already been shown to contain an appreciable amount of the principle acting against pernicious anemia.2 This report deals with preliminary observations relative to the presence in normal human urine of a substance which is perhaps identical with the hematogenic or antianemia principle

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