Dyke1 adequately studied the method of elimination of Staphylococcus through the kidneys and also the pathogenesis of the lesions produced by this organism. It was his opinion that the passage of organisms "from the blood stream to the urine occurs only as the result of the formation of lesions in the kidney substance. The steps leading to the formation of such lesions after the introduction of cocci into the blood stream appear to be something as follows: The first cocci to find their way to the kidneys are held up in the glomeruli and there destroyed. Later, coccic emboli lodge in the vessels afferent to the glomeruli; these multiply and give rise to abscesses in the cortex and boundary zone. Even before a definite abscess is established, organisms find their way through the damaged vessel walls and tubular epithelium and gain ingress to the lumina of the tubules."