In a previous communication1 we showed that in obese subjects in whom evidence of metabolic disorders (diabetes mellitus, including the prediabetic state, essential hypertension and arteriosclerosis) and arthritic disturbances (osteo-arthritis) was lacking the cholesterol content of the plasma was usually at a normal level. The advent of these degenerative diseases in the obese was generally accompanied by a rise in the plasma cholesterol.
The second phase of the problem, namely, a study of the variations in the blood cholesterol in obese subjects undergoing reduction of weight on a low caloric diet, is now reported. We wished to determine whether loss in weight while on a low caloric diet exerted any influence on the normal level of the plasma cholesterol in subjects with uncomplicated obesity and, again, whether the elevated plasma cholesterol in obese persons showing evidence of degenerative disease could be reduced by a similar diet.
MATERIAL AND METHODS