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July 1935, Vol 56, No. 1 >
ARTICLE | July 1935

ACTION OF OIL OF PEPPERMINT ON THE SECRETION AND MOTILITY OF THE STOMACH IN MAN

JACOB MEYER, M.D.; LOUIS SCHEMAN, M.D.; H. NECHELES, M.D., Ph.D.
Arch Intern Med (Chic). 1935;56(1):88-97. doi:10.1001/archinte.1935.03920010096006.
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While conducting experiments on the mechanism of pain in peptic ulcer it occurred to one of us to try the effect of essential oils. Oil of peppermint was selected because it is known as a household remedy for relieving gastric distress. This paper is a report of the action of oil of peppermint on the motility and secretion of the stomach of patients with peptic ulcer.

The "Pentsao Kang Mu" (Li Shih Chen, 1597 A. D.),1 in which is summarized the oldest knowledge of Chinese medicine, records the use of oil of peppermint as an antispasmodic. According to Heupke,2 peppermint as a remedy was mentioned at the time of Charlemagne.

Wallace and Jackson3 found that oil of peppermint in the intestine influences gastric secretion by reflex action. Meyer and Gottlieb in their textbook4 stated that carminatives increase the muscular activity of the alimentary canal. Muirhead and

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