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EFFECT OF TOXEMIA ON THE TOLERANCE FOR DEXTROSE AND ON THE ACTION OF INSULIN: II

J. SHIRLEY SWEENEY, M.D., Sc.D.; N. BARSHOP; L. C. LoBELLO; R. S. ROSENTHAL
Arch Intern Med (Chic). 1934;54(3):381-388. doi:10.1001/archinte.1934.00160150068004.
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The experiments presented in this paper are a continuation of observations bearing the same title and published at an earlier date in the Archives.1 It has been shown in previous studies2 that diphtheria toxin produces a toxemia in rabbits which lessens the animals' ability to remove dextrose from the blood as judged by the dextrose tolerance test. In animals poisoned with diphtheria toxin, after several days of toxemia, the blood sugar two hours after the administration of 5 Gm. of dextrose was found to range as high as 400 and 500 mg. per hundred cubic centimeters. Small uniform doses of insulin were then administered, and it was originally thought that a constant and uniform effect of the insulin could be noted as the toxemia increased. In our earlier study,1 daily increased doses of insulin were injected twenty minutes prior to the administration by stomach tube of a

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