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EFFECT OF TOXEMIA ON TOLERANCE FOR DEXTROSE AND ON THE ACTION OF INSULIN

J. SHIRLEY SWEENEY, M.D., Sc.D.; N. BARSHOP; L. C. LoBELLO
Arch Intern Med (Chic). 1934;53(5):689-698. doi:10.1001/archinte.1934.00160110058005.
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In a previous article,1 attention was directed to the effect of toxemia on the tolerance for dextrose. Rabbits were given injections of varying doses of diphtheria toxin, and daily dextrose tolerance tests were made, 5 gm. of dextrose being used. It was shown that, as the toxemia increased from day to day, the tolerance for dextrose decreased. Some of the animals that survived as many as seven or eight days of the toxemia acquired blood sugar levels as high as 400 or 500 mg. two hours following the administration of dextrose. The exact explanation of this phenomenon is not clear. It may be observed in normal human beings who are toxic,2 but is more strikingly seen in diabetic persons who are victims of infections. One of two explanations may be offered for such an effect on dextrose tolerance: (a) an increased glycogenolysis or (b) an inhibition of glycogenesis.

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