0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

ORIGIN AND SIGNIFICANCE OF TYROSINURIA IN DISEASE OF THE LIVER

S. S. LICHTMAN, M.D.
Arch Intern Med (Chic). 1934;53(5):680-688. doi:10.1001/archinte.1934.00160110049004.
Text Size: A A A
Published online

Disorders in the metabolism of tyrosine are observed in the inborn metabolic anomaly, alkaptonuria, and in so-called tyrosinosis. In the latter condition, tyrosine, dihydroxyphenylalanine, hydroxyphenylpyruvic acid and hydroxyphenyl acetic acid appear in the urine.1 Tyrosine is occasionally found in the urine in cases of cystinuria.2 tyrosinuria may also occur independently of any anomaly of metabolism. The substance has been recovered in crystalline form from the urine of a normal subject3 and in various pathologic conditions, mainly involving the liver and biliary passages.4 The unreliability of the crystalloscopic method of diagnosis was emphasized in a previous communication.5

Frerichs and Städeler,6 who first demonstrated the presence of leucine and tyrosine in the urine of a patient with acute yellow atrophy of the liver, established the basis for the belief that the amino-acids excreted in the urine in this disease are derived from the decomposition of the liver proteins. In view of the

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();