Czerny,1 in 1873, first used the term "osteitis defromans" to describe softening and deformity of the tibia and fibula in a young soldier. Paget,2 however, was unaware of this when he published his classic description in 1877 and suggested the term "osteitis defromans" because of his belief in the inflammatory nature of the lesion. Since that time, Roberts and Cohen3 stated, more than three hundred cases of the disease have been described. In view of the fact that within four years we have observed thirty-four cases, it would appear that the disease is much commoner than was hitherto supposed. The increasing use of roentgenography is probably the explanation.
The present investigation, originally commenced in 1926 as an effort to ascertain the frequency of neurologic changes in osteitis deformans, expanded into a more comprehensive clinical and biochemical investigation.
REPORT OF CASES
—History.—F. N., a