Arch Intern Med (Chic). 1934;53(1):153-158. doi:10.1001/archinte.1934.00160070158013.
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Comparatively little is known of the effect of insulin on sugar tolerance in nondiabetic persons. However, certain observations have been reported to suggest that the drug has an appreciable effect on this phase of metabolism. A temporary loss of carbohydrate tolerance during a period of administration of insulin was observed by Wilder, Smith and Sandiford1 in the case of two obese patients and by Paul, Clark and Gibson2 in five normal persons. Schellong and Kramer3 made tests for the sugar tolerance of fourteen thin women before and during insulin therapy and noted a more rapid rise and an earlier fall in the curves for blood sugar during the period of treatment with insulin than during the control period. Fricke4 administered dextrose by stomach tube to dogs without inducing glycosuria, but when the same dose of dextrose was combined with injections of insulin, glycosuria of short duration


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