1. The test proposed by Dr. Althausen is a test of dextrose tolerance. The method of blood sugar analysis which I used determines dextrose, and largely eliminates other reducing substances which might obscure the true picture of dextrose metabolism. The subject of glutathione, therefore, is irrelevant to this discussion, and it already has received more attention than it deserves. It is necessary, however, to reply to Dr. Althausen's last statements in this connection.
(a) All workers in this field are by no means agreed as to whether insulin produces augmentation of the sulphydryl bodies in the blood. Zunz remarks that Tateishi (Kyoto-Ikadaigaku-Zasshi 5:51, 1931) demonstrated sometimes a decrease of glutathione in healthy human subjects after injection of insulin, and both Cahane and Zunz refer to the work of Blanchetiè, Binet and Mélon (J. de physiol. et de path. gén. 27:1 and 19, 1929), who are said to have observed no