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ARTICLE |

IRON IN HUMAN BLOOD

ADOLPH SACHS, M.D.; VICTOR E. LEVINE, M.D.; ABRAHAM APPELSIS, B.S.
Arch Intern Med (Chic). 1933;52(3):366-377. doi:10.1001/archinte.1933.00160030027002.
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The recent enlightening researches on iron metabolism have given increased emphasis to the importance of iron in the blood stream. There are four interesting phases in which blood iron participates: (1) storage, (2) catalysis, (3) ferrification and (4) production of hemoglobin.

ACTIVITIES OF BLOOD IRON 

Storage.  —The factors determining the storage of iron in the body are indefinite, although in children it has been suggested that a higher intake of iron results in increased storage.1 In any event, the circulation figures prominently in this activity by transporting and distributing the iron stored in the body. However, the form in which iron is transported in the blood stream is vague. Free iron is known to be highly toxic in the blood stream. Its great affinity for nitrogenous complexes2 facilitates the assumption that iron occurs in some such union. One plausible explanation of the iron traffic designates the red blood

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