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ARTICLE |

THE SPECIFIC DYNAMIC ACTION OF PROTEIN IN PATIENTS WITH PITUITARY DISEASE

MARSHALL N. FULTON, M.D.; HARVEY CUSHING, M.D.
Arch Intern Med (Chic). 1932;50(5):649-667. doi:10.1001/archinte.1932.00150180002001.
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In the extensive literature on the specific dynamic action of food there have appeared a number of articles relating to the effect of the endocrine glands on this feature of metabolic activity. Experimental studies have led to varied conclusions as to the rôle played by the glands of internal secretion in altering the specific dynamic response to food. Foreign investigators in particular have reported finding this response diminished or completely absent in patients with diseases of the thyroid or pituitary gland.1 In this country Baumann and Hunt,2 Foster and Smith3 and others have noted an abnormal specific dynamic response immediately following the administration of dextrose or amino-acids in rabbits and rats deprived of their thyroid or pituitary glands. Some of the workers, notably Kestner, Liebeschütz-Plaut and Schadow,4 and Foster and Smith,3 have reported an increase in the specific dynamic action when preparations of pituitary gland

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