Immediately following Banting's announcement of a method of preparation that would permit insulin to be obtained in sufficient quantities to make its use in experimental work practicable, and more especially with the availability of commercial preparations of insulin, there has been an avalanche of publications on carbohydrate metabolism. This was natural and to be expected. However, in spite of the multiplicity of papers, our knowledge of the deeper significance of insulin is still disappointingly poor. There seems to be, also, a certain amount of confusion concerning some of the more obvious results of insulin administration. For these reasons it seems desirable to us at this time to present an experimental review of some of the simpler aspects of insulin activity.
In view of the abundant recent and excellent reviews of the literature that have appeared there is no occasion to burden this paper with what at best could be but