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JANET M. VAUGHAN, B.M., B.Ch. (Oxford)
Arch Intern Med (Chic). 1931;47(5):688-697. doi:10.1001/archinte.1931.00140230015002.
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In 1927, Minot and Murphy1 drew attention to the striking gain in body weight observed in patients with addisonian pernicious anemia who were given liver therapy, and this observation has been borne out by the majority of subsequent reports. This gain in weight occurs whether whole liver or liver extract is used. Meulengracht and Holm2 recently analyzed a series of thirty-six cases, with special reference to the gain in body weight, and showed that the average gain over a period of from one to two years was 54 pounds (24.5 Kg.), showing no appreciable difference in patients receiving extract or whole liver or a combination of the two. I3 reported the case of one patient treated with whole liver who gained as much as 20 pounds (9 Kg.) in one month. Wyckoff and Bloomfield4 cited the cases of two patients who were given extract only, and who gained 13.5 and


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