The popularity of this work is attested to by the appearance of this, the sixth, edition, the first edition appearing in 1908, since which time there have been many changes both in theory and in practice. So many notable changes have occurred in the six years following the appearance of the fifth edition, in 1924, that it has been found necessary to submit the whole book to a thorough revision. The author states, "In retrospect I am struck by two facts. One is the much closer association between physiology and medicine now than twenty-one years ago. The other is that a good indication as to the truth of new work can be gathered from the speed with which its effect is found to be spread beyond its original application. Insulin is an outstanding example of this; instances to the contrary need not be pilloried."
Fundamental discoveries in physiology and clinical