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Arch Intern Med (Chic). 1930;46(5):778-781. doi:10.1001/archinte.1930.00140170039004.
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This test was first described by Boltz1 in 1923 as a simple and specific spinal fluid test for dementia paralytica. Grossman,2 in 1925, and Harris,3 in 1926, essentially confirmed this report, Grossman adding that the white of an egg also gives a positive reaction. Walker and Sleeper,4 in 1927, questioned the accuracy of the previous results, and offered convincing evidence, mainly of a chemical nature, that the test is not specific. They stated that a positive reaction is due to a reaction between an aldehyde and tryptophan. In 1928, Myerson and Halloran5 reported that they had found that in spinal fluid a positive Boltz reaction is obtained whenever there has been an increase in protein from whatever cause, the degree of positivity corresponding closely with the quantitative increase in protein. They stated that it is not a specific test for dementia paralytica, and that it is positive in spinal fluid


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