Arch Intern Med (Chic). 1930;45(2):302-314. doi:10.1001/archinte.1930.00140080144011.
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This study is an effort to evaluate clinically certain so-called tests of liver function on the basis of the results obtained from their use in cases of known or anticipated diseases of the liver. The difficulties encountered in the application of functional tests to the liver have been commented on frequently in recent literature and have been concisely summarized by Carlson.1 A critical survey of the many liver function tests which have been introduced led Mann and Bollman2 to the conclusion that the tests which offered the greatest clinical possibilities were those concerned with the measurement of serum bilirubin and the excretion of specific dyes. These observations have been supported in general by the workers who have applied the tests to clinical material, the van den Bergh reaction and the icterus index being used in the study of serum bilirubin and one of the halogenated phenolphthaleins as the specific dye.


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