As the salts of lime form the greatest part of the inorganic portion of all the bones and of the teeth in the body, a study of the calcium metabolism in arthritis with bony changes is of interest. The mineral metabolism of the body is an important part of the general metabolism. Calcium salts are essential to most forms of life, and lime salts are present to a considerable amount in the tissues.
The present experimental study deals largely with the question of the calcium balance in the toxic type of arthritis. Two cases were studied intensively for many weeks. The first case was one of extensive hypertrophic osteo-arthritis in a woman, aged 60, who was more or less bedridden. The other patient was a woman, aged 55, who suffered from generalized atrophic osteo-arthritis. The following classification of arthritis is used.
Rheumatic: By this term acute rheumatic fever only is